Search

MORE NEWS
HEALTHCARE | Tony Chua, Singapore
Published: 07 Apr 11
1513 views


A*STAR scientists join forces with Servier to develop anti-cancer drugs

The partnership aim to develop drugs restricting the growth of tumor-initiating cells in breast cancer.

A*STAR’s Singapore Immunology Network (SIgN) has inked a Research Collaboration Agreement (RCA) with Servier, the second largest French pharmaceutical company in the world. The collaboration aims to develop anti-cancer drugs to suppress tumor-initiating cells (TICs), often called “cancer stem cells”. By targeting TICs, scientists hope to be able to prevent relapse and metastatic outgrowth in cancer patients.

Under this three-year partnership, SIgN and Servier aim to develop drugs directed at restricting the growth of TICs in breast cancer - the most common cancer in women all over the world, and also in Singapore with about 1,100 new cases diagnosed each year. Scientists at SIgN, with their expertise in tumour immunology and therapeutic antibodies, will be able to isolate TIC-specific human monoclonal antibodies, and with the help of Servier, develop them into anti-cancer drugs, accordinbg to an A*STAR report.

As Associate Professor Jean-Pierre Abastado, Principal Investigator of SIgN that will head the lab for this SIgN-Servier collaboration said, “Scientists and clinicians have been trying to understand why cancer relapse occurs in spite of the removal of the primary tumor. Basic research conducted at SIgN has shown that cancer relapse could potentially be avoided by controlling TICs. Our task at hand is to discover the monoclonal antibodies that will target these TICs.”

Dr. Emmanuel Canet, MD PhD, Head of Research & Development at Servier added, “This partnership exemplifies our vision to collaborate with leading scientists worldwide to discover and develop innovative medicines in the field of cancer where the medical need is still huge. We have been very impressed by the quality of the research work done at the Singapore Immunology Network (SIgN), which we believe is one of the best such institutes in the world.”

“Elimination of tumour initiating cells represents a major challenge in oncology. The aim of this collaboration is to develop an innovative approach to identify membrane neo-antigens specifically expressed by breast cancer stem cells. There is a great therapeutic potential since therapeutic antibodies against these neo-antigens could be used to control the residual disease by eliminating cancer stem cells persisting after conventional therapies", said Dr Stéphane Depil, MD PhD, director of Oncology Research & Development Unit at Servier.”

Prof Paola Castagnoli, Scientific Director of SIgN added “This project is supported by a joint lab between Servier and us and it will be located within SIgN. This is a strategy that we have already successfully developed last year with another company, in the field of Infectious Diseases. Pharma companies are very interested to develop new projects where they can find both an excellent scientific environment, together with unique technology platforms such as our fully human Monoclonal Platform and our Immuno-monitoring platform that can speed up the process of drug discovery.”

Chairman of SIgN, Prof Philippe Kourilsky commented, “I believe that this partnership with Servier will soon lead to the discovery of novel cancer drugs that will effectively control cancer relapse, enhancing the survival of cancer patients. I’m particularly delighted that this work stems from the results of basic research in Tumour Immunology conducted at SIgN. This partnership with Servier was made possible thanks to the powerful human monoclonal antibody platform that we have developed. This is an excellent example of how public research institutes and private companies can leverage on each other’s strength to come up with innovative solutions to address pressing medical needs such as fighting cancer effectively.”



Sign up for our newsletter

 

Do you know more about this story? Contact us anonymously through this link.

Click here to learn about advertising, content sponsorship, events & rountables, custom media solutions, whitepaper writing, sales leads or eDM opportunities with us.

To get a media kit and information on advertising or sponsoring click here.

Tags: A*STAR Servier, A*STAR Servier research, A*STAR Servier cancer drug research

CO-WRITTEN ARTICLES & SPONSOR CONTENT ››

Here's why Concorde Hotel Singapore and Putrajaya International Convention Centre lead the way in technology and building efficiency.
359 views

LATEST HEALTHCARE JOBS »
PRINT ISSUE »

Subscribe Now
What factors are keeping expats rooted in Singapore?

36 views

Can Asian private equity outgrow the west?

7 views

15 smart ideas to outwit the wiliest investment wolves this Year of the Sheep

12 views

MOST READ EXCLUSIVES

Singapore's 12 most influential business professors under 40

Singapore\'s 12 most influential business professors under 40

The youngest is aged 34.

by KRISANA GALLEZO
23 Oct 2014 | 71285 views
 

Singapore’s 7 hot new restaurants in September

Singapore’s 7 hot new restaurants in September

Have you checked out a very secretive cafe at 48 ¾ Niven Road?

by KRISANA GALLEZO
6 Oct 2014 | 26592 views

Singapore’s top 5 work from home jobs

Singapore’s top 5 work from home jobs

Here are jobs that you can do while sitting on your couch or in your favorite coffee shop.

by KRISANA GALLEZO
11 Dec 2014 | 15641 views
 

Check out General Motors’ new HQ in Singapore

Check out General Motors’ new HQ in Singapore

A ‘hot desks’ rule is implemented in the new office.

by KRISANA GALLEZO
3 Oct 2014 | 12320 views

Singapore’s 10 favorite meals on wheels

Singapore’s 10 favorite meals on wheels

You better cut the pizza: An Italian dish bagged the number 1 spot.

by KRISANA GALLEZO
17 Oct 2014 | 12060 views
 

Don’t settle for less: Legendary Hong Kong brings authentic and traditional HK dishes to Singapore

Don’t settle for less: Legendary Hong Kong brings authentic and traditional HK dishes to Singapore

The restaurant’s construction cost over a million dollars.

by KRISANA GALLEZO
3 Nov 2014 | 7405 views

Opera Estate welcomes a little bar simply called ‘Slake’

Opera Estate welcomes a little bar simply called ‘Slake’

It wants to be your living/dining room outside of home.

by KRISANA GALLEZO
25 Sep 2014 | 4839 views
 

The new Acronis HQ will make you feel like ‘walking into blue space’

The new Acronis HQ will make you feel like ‘walking into blue space’

Also, check out photos of its 7-eleven-like pantry amenities.

by KRISANA GALLEZO
28 Oct 2014 | 4483 views

Sofitel in Sentosa launches world's largest So SPA

Sofitel in Sentosa launches world\'s largest So SPA

Future plans are finally revealed.

by KRISANA GALLEZO
22 Oct 2014 | 4063 views
 

Want to know a ‘smart’ way to have your clothes washed?

Want to know a ‘smart’ way to have your clothes washed?

My Laundry Box introduces a smart laundry locker platform that works with an app.

by KRISANA GALLEZO
17 Oct 2014 | 3162 views

Could this be the most intelligent phonebook app yet?

Could this be the most intelligent phonebook app yet?

It’s self-updating and removes duplicates for worry-free contacts storage.

by KRISANA GALLEZO
29 Sep 2014 | 3055 views
 

Arete Culture opens first store in Lam Soon Building

Arete Culture opens first store in Lam Soon Building

It's a one-stop shop for your quirky interior decors.

by KRISANA GALLEZO
24 Sep 2014 | 3010 views

Do you want to build your own bike?

Do you want to build your own bike?

This store allows owners to creatively piece bike parts on their own.

by KRISANA GALLEZO
28 Oct 2014 | 2361 views
 

Hippy Tyrwhitt Road welcomes a resto-bar offering an all-day happy hour

Hippy Tyrwhitt Road welcomes a resto-bar offering an all-day happy hour

See how a radio DJ pursued his love for food.

by KRISANA GALLEZO
20 Oct 2014 | 1967 views

Singapore’s first news aggregation app attracts 1 million users in two years

Singapore’s first news aggregation app attracts 1 million users in two years

Stay in the loop with news and lifestyle content from SBR and 600 other publishers.

by KRISANA GALLEZO
10 Dec 2014 | 1383 views
 

This device is making a statement that hand-waving gestures are not usable

This device is making a statement that hand-waving gestures are not usable

It's a creation by 3 young computer wizards from Singapore.

by KRISANA GALLEZO
25 Sep 2014 | 1191 views

Jack Wills opens its first store in Singapore

Jack Wills opens its first store in Singapore

A 'fun' brand that values the Brit vibe. Put your game face on!

by KRISANA GALLEZO
10 Dec 2014 | 1188 views
 

World Cup 2014 might have ended but this anti-gambling campaign is far from over

World Cup 2014 might have ended but this anti-gambling campaign is far from over

Many suggested to put it down amidst criticism, but Goodfellas cannot be stunned.

by KRISANA GALLEZO
15 Oct 2014 | 1172 views

What Singaporean investors can expect from Okinawa’s development

What Singaporean investors can expect from Okinawa’s development

A 40% tax cut in setting up business is expected to lure investors.

by KRISANA GALLEZO
12 Dec 2014 | 1006 views
 

Now, hear this: You won't believe what your ears are seeing

Now, hear this: You won\'t believe what your ears are seeing

Ubersnap lets you upload photos with background music.

by KRISANA GALLEZO
2 Oct 2014 | 890 views

Kungfumath wants to revamp boring e-learning portals

Kungfumath wants to revamp boring e-learning portals

“Play with numbers” in its literal sense.

by KRISANA GALLEZO
5 Dec 2014 | 712 views
 

The future of innovation: What’s next after Facebook and Twitter?

The future of innovation: What’s next after Facebook and Twitter?

A video version of Twitter might be under way.

by KRISANA GALLEZO
11 Dec 2014 | 682 views

SFIC Institute's new training hub overhauls carpenters' career image

SFIC Institute\'s new training hub overhauls carpenters\' career image

It’s the first carpentry training center in Singapore’s furniture industry.

by KRISANA GALLEZO
10 Dec 2014 | 653 views
 

Inverted Edge gives spotlight to all independent contemporary fashion designers

Inverted Edge gives spotlight to all independent contemporary fashion designers

The homegrown startup has raised US$1.6M total funding in two years.

by KRISANA GALLEZO
3 Nov 2014 | 610 views

ENVision campaign‘s ‘hard truth’ could make you think twice

ENVision campaign‘s ‘hard truth’ could make you think twice

Singapore might run out of space for trash by 2035 and more.

by KRISANA GALLEZO
15 Dec 2014 | 240 views
 
close Don't Show Again

STAY INFORMED! Get our free weekly newsletter  

</